Discover FiteBac® Antimicrobial Technology

FiteBac® Antimicrobial
Cavity Cleanser

2% K21 QAS aqueous ethanol solution
FiteBac® Antimicrobial Cavity Cleanser removes debris in carious lesion preparations and penetrates exposed dentin tubules. This activity allows restorative adhesives to tightly bind to the prepared dentin surfaces while addressing residual microbial contamination within the restoration site.
FiteBac FT Bond

FiteBac® FT Bond

COMING SOON

5% K18 in a permanent acrylic based dental adhesive
Resistance to biofilm formation, loss of adhesion, and decay under permanent dental restorations.

Indications for Use: Permanent placement of dental appliances and restorations

Development Status: 510(k) submission Q2/2021

Target Audience: Prescription use for Dental Professionals

FiteBac CC Ortho-Seal

FiteBac® CC OrthoSeal

COMING SOON

5% K18 in a dental sealant
Resistance to biofilm formation around and under orthodontic brackets. Reduce risk of surface damage from white spot lesions. Improved cosmetic outcomes.

Indications for Use: Sealant applied to enamel prior to placement of orthodontic bracket adhesive

Development Status: 510(k) submitted Q4/2020

Target Audience: Prescription use for Dental Professionals

How does FiteBac® work?

FiteBac® K18 QAMS is a well-known
Si-Quat biocide covalently bound to a silane core containing acrylate functionality.

  • Acrylate functionality allows for
    co-polymerization within several polymer systems

Antimicrobials do not migrate from the polymer

  • Normal wear of a dental device exposes fresh K18 QAMS creating continuous microbiological protection

K18 QAMS has been FDA-cleared as a component in certain dental appliance resins

Patent protection until 2033.

K18 QAMS is an FDA 510(k) Cleared Antimicrobial MMA/PMMA Acrylic Resin System. The addition of K18 QAMS to an MMA/PMMA acrylic resin has been shown to improve fracture toughness without adversely affecting flexural modulus and strength of the orthodontic acrylic.1

 

In vitro studies, performed by Dr Frank Tay, Dental College of Georgia at Augusta University, of orthodontic acrylic resins containing 4–6% K18 QAMS have been shown to possess both in vitro immediate diffusional as well as contact-killing antimicrobial properties when tested with Streptococcus mutans, Actinomyces naeslundii and Candida albicans.1

1. Gong SQ, Epasinghe J, Rueggeberg FA, et al. An ORMOSIL-containing orthodontic acrylic resin with concomitant improvements in antimicrobial and fracture toughness properties. PLoS One. 2012;7(8):e42355.

FiteBac® K21 QAS consists of 4 Silane Quaternary Ammonium structures covalently linked to a silane core.

Studies have shown that K21 QAS demonstrates:

  • Does not negatively impact adhesive bond strength to dentin2,3
  • Excellent antimicrobial activity2,4
  • Improves infiltration of adhesive monomers into acid etched dentin2
  • Inhibition of MMP-9 and Cathepsin-K2,4

Patent protection until 2033.

2. Gou YP, Li JY, Meghil MM, et al. Quaternary ammonium silane-based antibacterial and anti-proteolytic cavity cleanser. Dent Mater. 2018;34(12):1814-1827.

3. Daood D, Yiu CKY, Burrow MF, Niu LN, Tay FR. Effect of a novel quaternary ammonium silane cavity disinfectant on durability of resin-dentine bond. J Dent. 2017;60:77-86.

4. Umer D, Yiu CK, Burrow MF, Niu LN, Tay FR. Effect of a novel quaternary ammonium silane on dentin protease activities. J Dent. 2017;58:19-27.

Indications for Use: Intended for cleansing and moistening/re-wetting of cavity preparations

Development Status: Cleared for marketing in the United States

Target Audience: Prescription use for Dental Professionals

Instructions for use
Safety Data sheet
FDA 510K

K-18/Ethanol Pre-Bonding Agent

a.) Enhances bond strength of bonding agents from various companies.
b.) Penetration greater than 100um into etched dentinal tubules helping to occlude tubules
c.) Reduces sensitivity to exposed dentin
d.) Inhibits MMP and Cathepsin activity from etched dentin
e.) Reduces micro-leakage at hybrid layer of restoration produces cell death of bacteria

K18 Additive to Several Bonding Systems

a.) Enhances the bond strength of the systems
b.) Inhibitor of MMP and Cathepsin
c.) Reduces micro-leakage at hybrid layer on dentin Additive to Composite Materials
a.) Significantly reduces acylate shrinkage
b.) Maintains antimicrobial activities throughout composite system

Additive to All Resin and Resin Modified Cement

a.) Enhances durability and toughness
b.) Maintains Antimicrobial

Additive to All Types of Dental Glass Particles by Functionalizing Instead of Silanizing

Additive to all Bis-Acryl, UDMA, PMMA, and Poly R Methacrylates where R represents either Ethyl, Vinyl, Isobutyl
a.) Improved fracture toughness, durability, and flexural strength

Additive to Endodontic Sealers MTA, Epoxy, CaOH, etc.

Dental Varnish After Dental Prophy

K-18 Additive to Glass Ionmer Restoration
a.) Enhances toughness
b.) Antimicrobial throughout materials

Dental Research